I am a second year graduate student at the University of Michigan in Dr. Anna Mapps Lab. I graduated from Jackson State University in 2015 with a B.S. in Chemistry. My research takes place within the process of transcription where I look to investigate allosteric communication of a targeted protein-protein interaction that plays roles in tumor progression and metastasis. My long term research interests are in drug development targeting protein-protein interactions, an area in which success has historically been very challenging.
Dissecting the Med25-PEA3 Complex
Med25 is a coactivator that binds PEA3, a subfamily of Ets transcription factors. PEA3 transcriptional activation domains (TADs) directly interact with the ACID/PTOV domain of the Mediator complex subunit Med25 and play important roles in tumor progression and metastasis. There are several lines of evidence that indicate this direct binding interaction between Med25 and ETV/PEA3 is required for function, there are few details regarding the complex. Med25 AcID is structurally distinct from other coactivators yet mechanistically homologous, suggesting that there is a conserved mechanism for coactivator-activator complex formation and regulation. These studies investigate Med25’s binding modes and eventually provide means for recognizing allosteric binding sites for small molecule targeting of the diseases relevant to each transcriptional complex.