I was born in Chillicothe Missouri in 1991 and stayed through high school. I attended Missouri Western State University, and received a BS in Biochemistry and Molecular Biology in 2013. Next, I became a KU Jayhawk, and started working towards my PhD in Chemistry under the guidance of Paul R. Hanson. My research involves the synthesis and evaluation of electrophilic sultam scaffolds as probes for biological pathways.
Intramolecular C-Vinylation for the Synthesis of Structurally
Unique Electrophilic Triazole-Fused Vinyl Sultams
The development and discovery of chemically unique scaffolds capable of modulating nucleophilic residues in proteins found in biological pathways involved in human health and disease is the primary goal of this study. In this regard, the development of rapid and robust methods capable of generating diverse scaffolds, that allow for the attenuation of structural, electronic and stereochemical parameters are sought. In pursuit of this goal, an intramolecular C-vinylation synthetic route has been developed for the construction of electrophilic triazole-fused exo-vinyl sultams. This highly efficient method enables the synthesis of a library of diverse sultams. The investigation of the electrophilic character of these exo-vinyl sultams is currently being studied using a variety of small nucleophiles such as thiols and amines.