My team of ~45 has 3 sub-groups: top down proteomics, natural products discovery, and cancer epigenetics. To improve proteomics for both basic and translational research, we show that protein analysis without digestion is possible!
Dr. Kelleher’s laboratory has three main sub-groups working in the areas of Top Down Proteomics, Natural Products Biosynthesis/Discovery, and Cancer Epigenetics. The Kelleher group has been successful in driving both technology development and applications of high performance mass spectrometry at the interface of chemistry and biology. Since 2011, Dr. Kelleher has served as the director of the Proteomics Center of Excellence at Northwestern University, where dozens of Northwestern laboratories are supported and beyond state-of-the-art in Top Down proteomics is developed. Dr. Kelleher was elected Treasurer of the American Society for Mass Spectrometry in 2012 and established the Consortium for Top Down Proteomics that same year. In September 2012 Dr. Kelleher gave the keynote address at World HUPO (Human Proteome Organization), where he described a “Top Down” version of the Human Proteome Project viewable at this URL (http://www.kelleher.northwestern.edu/human-proteome-project/the-talk). With more than 200 papers published over the course of his career and teaching duties in two departments, Dr. Kelleher is a trans-disciplinary investigator with visible streaks of international impact in mass spectrometry-based proteomics and the discovery of new natural products from the microbial world. Validation of protein-based biomarkers in organ transplantation and cancers of the blood are among the focused areas currently being pursued in clinical research at Northwestern.