“Huskers and Badgers are nice, but Wolverines are awesome!”
Anna Mapp completed her A.B. in chemistry at Bryn Mawr College before moving to the University of California-Berkeley to complete the PhD under the direction of Professor Clayton H. Heathcock. Following postdoctoral work with Professor Peter Dervan at Caltech, Mapp joined the faculty at the University of Michigan in 2000, where she is currently Professor of Chemistry and Director of the Program in Chemical Biology.
Much of our research focuses upon developing a molecular-level picture of inducible gene expression in eukaryotes using organic molecules as mechanistic probes. Regulated gene expression is critical for cellular existence, and a number of human diseases such as cancer and diabetes have been linked to aberrant patterns of gene expression. Therefore, a goal of primary importance in the scientific community is the discovery of transcription-based therapeutics capable of reprogramming gene expression in diseased cells while leaving normal cells unaffected. While a general sequence of events that leads to gene up-regulation is agreed upon, the molecular-level interactions that regulate the levels and time course of transcriptional activation remain unknown. A more detailed picture of gene regulation is a prerequisite for the eventual development of transcription-based therapeutics.